This early research helped shape Dr. Folkman's research career, as he worked to prove that tumors require a dedicated blood supply and secrete a protein to promote vessel growth. Though not always believed, Dr. Folkman postulated that the process of angiogenesis was a key factor in the transformation of a set of mutated cells into a large malignancy. His theories led to the development of some of today's most investigated drugs—angiogenesis inhibitors, such as Endostatin.
It was also during his time in the Navy that Dr. Folkman reported the use of implantable rubber polymers for sustained release of drugs, leading to the concept of controlled-release technology for drug delivery.
Dr. Folkman gave the keynote address during the AUA Annual Meeting in Chicago in 2003.
Visit the Academy of Achievement to view more photos and an exclusive interview with M. Judah Folkman, MD