Early on, he was interested in scientific research and, in the 1950s, began to relinquish his surgical activities bit by bit. Dr. Huggins was known for his curiosity, creativity and almost old-fashioned hard work, frequently coupled with his delicate humor. His first major research dealt with induced transformation of one cell type into another, transforming fibrous tissue into bone by implanting bladder epithelium in a different host site. Dr. Huggins wrote about this: the actual value of this spectacular experiment was to lead a young practitioner into the delights of discovery in the exciting world of research.
His next research activity dealt with the relation of body temperature to hematopoiesis in bone marrow. This work, based on transplantation of bone marrow from a rat tail into the abdomen, resulted in one of the three gold medals he received from the American Medical Association.
As Dr. Huggins was asked by his patients about the function and purpose of the prostate, he realized that for both normal and