diseased states, very few research papers existed. In the late 1930s (with his students Clarence V. Hodges and William W. Scott) he studied the relation between the endocrine system and function of the prostate gland, and later the control of inoperable prostate cancer. Until then metastatic pain had been treated by a radiation of nerve roots and through successively larger doses of alkaloids.

Hormonally-induced regression of prostatic carcinoma, and particularly the resolution of pain, was many times quite spectacular. "Humanity owes a great debt to Charles Huggins," said Paul Talalay, director emeritus of the pharmacology department at The Johns Hopkins University and a previous student and collaborator of Dr. Huggins.

In October 1966, Dr. Huggins received the highest decoration in the scientific world, the Nobel Prize for Physiology and Medicine, jointly with the virologist Peyton Rous. It honors the importance of Huggins' work and research that influenced other scientists and their research relating to the behavior of cancer cells. His discovery opened an era

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