After the first two years in medical school, during which he took all the electives in physiology and biochemistry, Dr. Scott decided to follow in his two brothers' footsteps and work toward a doctorate in physiology. His doctoral thesis was "The Physiology of Cerebral Concussion," and for a time he considered going into neurosurgery. However, after he obtained his medical degree and interned in surgery under Dallas B. Phemister, MD, a strange set of circumstances pushed him toward urology. Dr. Scott worked with Charles Huggins, MD and later became his resident and associate. Dr. Scott's experiences with Dr. Huggins convinced him that he wanted to pursue a life in urological surgery and research.

Aside from his work on the prostate gland, Dr. Scott had an interest in renal transplantation. In the early 1950s he was the first—with Johan de Klerk, MD and H. William Scott, MD—to use cortisone in an effort to increase the length of survival of heterologous renal transplants in dogs.

In Dr. Scott's 1965 presidential address to the Mid-Atlantic Section of

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